Thursday, September 26, 2019

What Should Be The Policy of The Social Network Based Corporations on Research Paper

What Should Be The Policy of The Social Network Based Corporations on The Use of Internet For Illegal or Criminal Activities - Research Paper Example It can be affirmed that a well-built or a relevant internet policy plays an essential role for an organization to protect credential information from any external threat. Moreover, the intermediaries associated with social media services also incorporate adequate provisions that ensure to prohibit users to practice different illegal activities. In relation to the present day context of rapidly growing vulnerabilities, the social networking service providers are likely to develop effective privacy policies to prevent users from being affected with the conduct of various criminal and unlawful activities.Moreover, the internet service providers in the global domain tend to adopt along with implement highly developed privacy policies concerning easy accessibility of internet usage due to growing vulnerabilities. In this regard, the internet policies of the global marketers highly incorporate strong regulations in order to protect information of the social media users along with their cre dentials from external threats.... ime, it has been witnessed that a growing number of unlawful or criminal activities by the users are performed through different social media and blogging internet sites. In this present day scenario, it can be viewed that the users often face certain threats while performing different activities in the online social media networks. In this regard, the organizations such as Google, Facebook and Twitters among others are highly focused on building strict policies in order to prohibit the conduct of various illegal activities associated with terrorism, sexual abuse and other similar practices through social networks. The security policies of the present social media websites ensure to keep the track of each user, regarding their posts along with comments made by their peers and other suspicious users. The provisions underneath the privacy policy of the aforesaid organizations also incorporate adequate measure concerning age, gender along with other determinant factors for reducing pote ntial hazards from the criminal issues. With respect to the policies associated with privacy of user contents, the organizations also tend to conduct user verification process in order to keep adequate safety of information along with personal contents. Moreover, the process also enables the organizations to prevent the conduct of illegal activities through the usage of internet medium (Vacca, 2012). 4. Government Policy Options With regard to determine the phenomenon of extensively growing number of social media users, the governmental policies along with the regulations can be apparently observed to frequently involve continuous development in protecting the abusive use of internet. The federal law associated with the use of internet comprises numerous policies that ensure effective use

Wednesday, September 25, 2019

Google verses Microsoft Research Paper Example | Topics and Well Written Essays - 1750 words

Google verses Microsoft - Research Paper Example They offer a variety of IT products that include the operating systems, design of site operations by companies, products that facilitates efficient advertising. The company majorly engages in the provision of search, advertising, operating system platforms, and enterprise services in general. Microsoft on the other hand does not deal so much on different products than those of Google. Microsoft came into existence in the 1980’s with the major object of ensuring that business IT solutions are well effected, it offered the earlier IT services that included the Microsoft office tools which it has kept upgrading till recent. Its latest product is the Bing, which has been developed to counter the Android that is a product provided by the Google incorporation. Microsoft had been divided into five divisions in terms of the product, hence termed as product divisions. They include; Windows and Windows Live Division, Server and Tools, Online Services Division. All the above are engaged in the production and distribution of operating system products including their upgrade components, Microsoft Business Division; this departments is that which is engaged in the actual business operations which ranges from management to marketing, this department is that which fuels the objectives of helping businesses achieve active business solutions. Entertainment and Devices Division takes care of the entertainment sector. This is a major revenue-generating center for Microsoft incorporation and the corporation derives most of its income from this branch of the division. Microsoft employs the Total Quality Management style (TQM) of leadership. This is a management style where the every employee in the organization employs a proactive measure to ensure that the VMO’s of the organizations are met. Total Quality management also involves management by providing services high quality services that can withstand international completion. Google on the contrary employs a sought of beaurcratic management leadership style where a chain of command flows from the CEO downwards (Vise, 2008). Other competitors are Apple, twitter, Face book which are also IT service companies in the industry. Google financial ratios Name Formula 2008 2009 2010 Current Ratio Current Assets/Current liabilities 8.7 10.6 4.1 Return on Asset EBIT/Total Assets 8.4% 5.8% 5.1% Return on equity EBIT/Shareholders Earnings 13% 16% 14.1% Debt ratio Total debt/Equity 8.1% 7.6% 2.1% Fixed asset turnover Inventory/Fixed Assets 32.2 41.2% 21.4% Dividend payout ratio Earnings/Ordinary Shares 1.8% 2.1% 2.7% P/E ratio MPS/EPS 1.18 2.86 3.27 The movements in their financial ratios determine the performance of any company. The ratios as identified above are determines the liquidity of the company, profitability, the long-term prospects, and even the growth of the company. Liquidity on this case is shown by the current ratio. The current ratio shows the value of current assets as compared to the liabi lities of the companies. Google has high progressively increasing current assets ratio. This shows overcapitalization. It therefore means that, Google has invested much on Current assets than they have liability. The impact of this is that the company risks having liquidity problems in the future since the since it does not have an appropriate liquid cash to undertake their day-to-day operations. Profitability ratios are return ratios that depicts the profitability trends of the company. It is normally the wish

Tuesday, September 24, 2019

Glass Frames Essay Example | Topics and Well Written Essays - 1500 words

Glass Frames - Essay Example Initially glasses were for rectification of the eye problems, but the current situation several other glasses types are made either for fashion or for specialized jobs such as the welding glasses or polarized marine glasses. Glass lens has been in use for a long time, but the use of plastic lenses is of recent times beginning in 1952. The success of plastic was based on the inability to break. Over time, the material of choice has changed to plastic, but glass lenses are common. Currently, the process of manufacture has been customized enabling production on site (Greeff and Ghoshal, ,2004, p. 89). The raw material being â€Å"blanks† which are plastics formed to close to exact size by the optical laboratory. Market need The glasses demand has been changing significantly with the initial use being superseded with other uses. Traditionally they were use for study and called the reading glasses, but the situation has change and in 2008 majority of shopping of glasses was based o n fashion buys. Today it is common to see in the society sunglasses and some other types of glasses used either for fun or in functions such as funerals. The use of glasses has increased thus increasing demand for fashion glasses among other glass types. The demand has increased for eye glass thus creating the need for the manufacture of glasses. The demand is of the Eye glasses is evidenced by the increased in number of production units throughout the world. Customer’s requirement for frames Frame component Customer need No of respondent Importance Lug/End pieces Strong and durable to hold hinges 3500 Improves durability of the eye glasses Arm length Comfortable, strong and fitting 3490 Improves on the use of the glass and lead to the increased Ergonomics bridge Strong and rigid to hold lenses without failure and 3500 For proper functioning of the glasses Nose pads Soft to support the weight of the eye glasses while cushioning the impact of the weight on the nose 3498 Ensure s no injury t the nose while improving comfort ability of the eye glasses Total participants in market survey 3500 From the market research done on the quality of the eye glasses frames, It is evident that durability, and comfort are the important aspects of the final product. The desired quality by the customer affects the material choice, as such, for the eye glasses frames. The first choice material is Flexon an alloy which not only meets the customer’s specifications but also has the flexibility to return to the original form conditions termed as memory’ factor. Product design specifications The Eyeglass frames are available in an immense variety and sizes and comprise of several parts, which may not be joined together directly, but are vital in the performance of the glasses. The material of construction of the frames of the Eyeglass has been changing significantly with recent materials being indestructible whilst making the product light and comfortable in the pr ocess. Frame front: the front part that holds the lenses in place while bridging the nose thus connecting the two lenses Rims: are also called the Eye wires, they surround the edges of the lenses thus holding them in place. The lenses are usually inserted into the rims. This part may not be important today because glasses can be produced without it. Bridge: as the name suggests, it is the part that joins the two lenses over the nose and usually support 90% of the weight of the glasses. End

Monday, September 23, 2019

Educate parent attending accidebt emergency how to manage childs fever Research Proposal

Educate parent attending accidebt emergency how to manage childs fever at home - Research Proposal Example Managing childhood fever, will aid reduce various parental complaints for fever and reduce the chances of children death or complications resulting from unmanaged fever. Ways of maintaining fever at home Parents determine their children fever via behavioral changes they mainly link to fever. Parents realize immunological advantageous impacts linked to fever and some belief that fever is harmful and causes brain damage and convulsion of febrile. Therefore, to prevent adverse effects of fever, parents must monitor body temperatures of their children, use antipyretics, ensure their children wear light clothing and wash them with cold water or tepid. When a baby has a bacterial or viral infection, it is obvious for him to develop a fever and the fever will not harm the child, (Douglas 23). Children under the age of six months should seek medical attention while older children may be treated at home. Nevertheless, they should be presented to the hospital for medical attention if the fever last over two days. Methods of taking a child’s temperature There are various ways of taking a child’s temperature at home, for instance, rectal, oral (mouth), under the armpit and in the ear (tympanic). The correct method depends on the age of the child. The parent should ensure that the measurements are accurate. For example, using rectal method is the most accurate way, but most children under the age of two do not like this method. Even though, using axillary method is not extremely precise, it may help parents to know whether their children have fever, (Berger, Ann, John and Roenn 41). Temperature management Conventional treatment Various over the counter medications can be administered to manage fever at home, for instance, acetaminophen, aspirin and ibuprofen. Parents should avoid aspirin use because aspirin may lead to adverse side effects, such as fatal Reye’s syndrome leading to inflammation of the brain and vomiting. Parents can manage their children ’s fever by utilizing a cold sponge, and encouraging their children to take increased amounts of cold liquids like ice pops. It is healthy to give young children increased amounts of fluids contain electrolytes because fever quickly dehydrates them. The cold liquids aids cool the body and keep the baby hydrated. One can also use a fan. Always set the fan at minimal setting and direct it to have the air circulation around the child and avoid blowing the air directly to him, (Douglas 26). Additionally, reduce clothing layers so that the baby can lose increased eat easily through the skin. In addition, dress that baby in light clothing and let her stay indoors or under shade to reduce body temperature. Similarly, parents can manage fever in children by giving their children a lukewarm spongy bath. The body cools as the water evaporates from the skin, thus the body temperature lowers. For instance, if the body temperatures are too high, place a wet or damp piece of cloth on the f orehead of a child as she rests. In addition, the parent should ensure that the child gets enough rest. Since fever is because of a potential infection, a child’s body requires plenty of rest or sleep to fight off the agent causing the infection. Experts agree also that having fever makes a child feel exhausted and achy. Therefore, during this period, parents should motivate the children to have plenty of rest

Sunday, September 22, 2019

Classroom Management Essay Example for Free

Classroom Management Essay Classroom management and discipline are two very important building blocks in a successful classroom. Setting rules and expectations for students has many positive benefits. Not only will students feel more comfortable in a stable well managed classroom, they will also learn more because there will be less distractions. Students in a classroom that are well managed will also retain the information for longer periods of time rather than just for the moment to make a good grade. Teachers want more than anything for their students to learn life skills that they can carry on with them into the future. Teachers want their classrooms to be a place that students look forward to attending to learn and feel safe and relaxed. In any classroom teachers want there to be mutual respect among teacher and students. In a classroom everything is to be organized and in its place, this will make it easy to move on from one subject or activity to the next without distractions. Colorful classrooms will make a fun and inviting environment for all kinds of students. Teachers should not want to have bland classrooms that bring the mood down with nothing fun or happy to look at. A classroom where students run wild and do whatever they want will not work for teachers or students. Many time school is not taken as seriously as it should be especially in younger grade levels, these are the years that form the minds of children, and their experiences in the classroom will have an effect of how they form into young adults. Most believe that all students have the want to learn. Fourth grade is about the time that students start paying more attention to their peers and surroundings. All students want to feel that they belong and be in an environment that they feel comfortable in. Therefore as a teachers it is their job to make sure that attention is paid to what the students are telling teachers even if they are not saying it out loud, and also to make sure that they are helped to learn not only what is written in the books, but also help them to learn about themselves. Section 2: Positive Climate A classroom is a place where teachers want students to love to be. First and most importantly all classrooms will have a set of rules and expectations that will be followed by teachers as well as students. If teachers do not set a good example in their classrooms, rules set for students will not be successful. The desks should be lined up in perfect rows making it easy to navigate around them, and give the students plenty of personal space. All the colors of the rainbow in a classroom make it a happy bright place. There will be posters on the walls with fun facts for students to read, along with classroom rules and expectations. A section full of pillows for students to relax and read, along with a section for games and group activities are positive spaces to have in a classroom. A great classroom will allow students to explore and learn on their own as well. As students are welcomed into the classroom, they will be met at the door with a happy smiling face and an excited positive attitude. The students will be allowed to find their desks, which will have their names on them, which will in that instance give them a sense of belonging. There will be games played on the first day to lighten the mood and help everyone get to know one another. Section 3: Rules, Consequences, and Procedures. The rules that will be established in a classroom should not be large in number. They will be rules that will keep the classroom running smoothly and keep students happy and respecting the teacher as well as their peers. With a solid easy to understand set of rules a teacher should expect that there will be a positive outcome. Starting with the first day of class rules and consequences will be established with all students. This information will be posted on the wall so that students can always see the rules to be reminded of what is expected of them. These rules and consequences are not to be used to make students afraid or uncomfortable, it’s so they will be shown and explained in a positive way, maybe even by playing a game to lighten the fact that there are rules that must be followed at all times. Rules: 1. Show respect to yourself as well as others 2. Keep hands and feet to yourself 3. Pay attention and follow directions 4. Raise your hand before speaking in class and use your indoor voice 5. Be prepared to learn Consequences There is a consequence to students’ actions whether it be a positive or negative one. Every week there will be a new chart made by the students with their names and five spaces for each day of the week, by allowing the students to make the charts themselves it gives them a way to express themselves and individuals. During the week their behaviors will be monitored and they will receive red dots for good and blue dots for bad behavior, at the end of the week the person with the most red dots will get a special treat. All the other students who have red dots will have a down time to read or play games. Students with blue dots will have to sit at their desks and go over the lesson or read silently, and not chat with their peers. If behavior is bad throughout the week and is becoming a habit the student will be taken aside and talked to. Not in a negative way but in a way to try and figure out what the teacher and student can do as a team to make the situation better. Make sure to ask the student if they may have a solution for the problem at hand. Procedures: 1. Restroom – ask, take bathroom pass, wash hands before returning to class. 2. Asking questions – raise hand and wait to be called upon 3. Turning in work – when work is complete quietly walk to the front of the room and put assignment in correct bin. 4. Needing help – place the red dice on the top of your desk and teacher will come to help with questions. 5. Changing activities – replace all materials being used, move back to desk and get materials ready for next assignment. Section 4: Specific Discipline Procedures or Measures Preventing bad behavior in the classroom may seem impossible, but in all honesty it may be attainable. If teachers keep a well managed classroom and their behaviors shadow the expectations that are given to the students, good behavior will be the outcome. By having all rules and expectations in an area where all students can see them, they will be reminded of them and be more likely to follow them. By having consequences for good and bad behavior this will help students to practice good behavior because they will already know the outcome of their actions. All desks will be facing the teachers desk so that they can see the teacher at all times. Keeping them in straight rows will also help students in keeping their hands and feet to themselves because they will all have adequate room. The white board where assignments are written, and the board with their behavior charts will be at the front of the class as well so they may see them at all times also. To help students who misbehave the teacher should take the time out to speak to the student in a one on one setting, giving the student the chance to explain themselves, and maybe express why they are behaving the way they are, and what steps they think they may need to take to fix the problem at hand. Teachers should not act as if they know what the problem is and how it should be fixed without giving the student a chance to speak as well. Good behaviors should be acknowledged as well, do not only focus on the bad. After speaking with the student take steps to help with behavior by asking the student how they are doing and if there is anything more you can do to help. If behavior continues to be bad, maybe taking a step for after school one on one time should be used to further access the problem. If a student violates school board policy, state regulations, or criminal laws steps outside of classroom discipline will have to be put into motion. If a student ever breaks any of these rules, school officials as well as the students parents will be called and actions will then be taken to fix the situations. Section 5: Approach to Discipline Personally I prefer Ginotts’ approach to discipline. I like the fact that he thinks the student should have the chance to express their opinion in the situation. By the teacher showing respect for the student and their thoughts I think this would be a very good approach because you gain the respect and trust from the student by showing them the same. There are times that I know that I am correct in a given situation, but I do not like to act as if I know everything; I like to give the other person a chance to make their case and explain why they feel the way they do. As I person I do not like to make people feel foolish so I respect every opinion and give mine in a nice respectful way. That is why I think that Ginott’s style fits my personality.

Saturday, September 21, 2019

Animal Research In Psychology Health And Social Care Essay

Animal Research In Psychology Health And Social Care Essay Throughout its short history of recognition as a legitimate experimental field of study (in 1879 when Wundt founded the first laboratory dedicated to psych research) and subsequent diversification into specialised areas, psychology has utilised and in some cases depended upon the use of non-human animals in research. For just as long, this practice has been contested. Views on the subject of animals in research are polar opposites and the debate appears to hinge upon two issues, first does the scientific use of animals lead to valid, useful and relevant results, and secondly, is it permissible for one species to cause pain, suffering and death to another to achieve aims that primarily benefit the former species? Answering these two questions is fraught with difficulty, not least by virtue of the many different variables that require consideration. To answer in the negative as to the utility or practicality of outcomes should leave the matter there, and the use of animals in research discounted, however, as in all scientific research, conclusions can not be drawn from a single instance, and successes in some experiments while there may be failures in others is not conclusive evidence. Further the validity and usefulness of results may be subjective; it is not unusual for scientific studies to be challenged years later on, nor methodology found to be flawed. To answer the first proposition in the positive brings us crashing to the hurdle of the second, much debated issue of whether animals are conscious, moral beings to whom rights should be accorded. Even the question of whether the animal model is an appropriate comparator with humans requires the involvement of animals in the research. The word research carries with it a somewhat negative connotation, and conjures images of secretive men in white coats with unfamiliar surgical implements and ulterior motives. Many people may be surprised by how much research is conducted outside of the laboratory and by whom, so one of the barriers to understanding the role of animals in research is a dated perception based loosely on poor historical practices or B-grade horror films. Research involving animals is varied in both its nature and purpose, in the types of animals involved and in the effect that it has on them. Some psychological research could be described as having negligible impact on the animal, for example observation studies in natural settings. Other experiments may actively engage animals in all manner of degrees, and although it is the most extreme of these (such as those involving mistreatment or torture) which raise the ire of those in opposition to use of animals in research, detractors rarely draw the disti nction with those experiments that are of specific benefit to animals or the preservation of the species, this includes advances in the field of veterinary science. Also escaping consideration is the fact that psychological research using animals has been instrumental in the training and study of medical assistance and companion animals, and in the development of pet therapy, all of immense benefit to humans. Humans seem to be selective in their outage. Researchers argue that behavioural studies using animals can provide an insight into the behavioural processes of humans and other species (Herzog).It can be argued that psychology, as a science of behaviour and mental processes, includes, by necessity, the study of animals to help researchers better understand how animals, both human and non-human, develop and function. The practice of using animals in research has allowed for significant advances across the fields which make up the science and has been central to the development of psychological theories. Without animals, comparative psychology is unviable, and researchers understanding of cognitive processes, evolution, social and mental development, and the ability to treat psychological dysfunction is severely compromised. The devil, however, is in the detail. The use of animals in psychological research has come under increasing scrutiny over the last 50 years. Throughout the 1960s and early 1970s Harlow was conducting controversial isolation experiments with monkeys which involved the total isolation of the animals for up to 24 months. Not surprisingly the animals emerged emotionally disturbed from the experience. (Harlow) This reignited the ethical debate regarding animals in research among scientists and academics and illuminated the fact that there was a sliding scale of belief or justification for the practice. (Bowd). The anti-vivisectionist movement which grew up around professionals like Singer, Benson and Clark in the mid 1970s had a huge impact on the medical and scientific communities, accusing researchers of cruel treatment of animals while delivering few practical applications (Bowd). Singer was especially critical of behavioural research stating simply either the animal is not like us, in which case there is no reason for performing the experiment; or else the animal is like us, in which case we ought not to perform an experiment on the animal which would be considered outrageous if performed on one of us. (p. 52, Singer) Experiments involving the infliction of pain or suffering on animals was receiving particular attention and M.A. Fox, who was a defender of experimentation, defined criteria emphasising the benefit to scientific knowledge, limiting the negative effects on the animal, and the exploring of other equally effective alternatives to the use of animals.(Bowd) Still, there were others who, not satisfied with this concession, further constrained this criteria. Bowd () contends that whether a procedure is inherently objectionable depends upon an analysis of the needs and nature of each species, in essence, Rollins rights principle ( Rollins 1985 in Bowd). Emerging from this however was a general consensus that research where the benefit to humans was outweighed by the cost of animal suffering (a utilitarian approach) was unnecessary and should be deplored. Whether by sheer coincidence, or in response to public concerns (and bad publicity) stirred up by the anti-experimentation lobby, professional associations with an interest in research began to release their own codes of ethical conduct and dedicated guidelines regarding the use of animals (American Psychological Association, 1981; British Psychological Society, 1986; Canadian Psychological Association, 1986). In most jurisdictions this is now supported by legislation and or Government issued codes of practice. In Australia, it has been left to the individual states and territories to regulate and oversee the use of animals in research, there being an absence of Commonwealth legislation. This is achieved through the instrument the Code of Practice for the Care and Use of Animals for Scientific Purposes (the Code), developed by the National Health and Medical Research Council. The Code utilises what is termed as the 3 Rs approach: replacement (with other methods), reduction (in number s), and refinement (of techniques). Several general principles which govern the use of animals in education and research have been adopted in many countries as the benchmark procedures aimed at minimising the use of animals in research. These developments may reflect an attempt to reign in the debate and to put it back into the science domain where it belongs. The sustainability of animal research is reliant on the preservation of scientific integrity and due deference to ethical concerns, and in this respect the Code and legislation strike a reasonable balance. Regulation attempts to monitor and define the way research is conducted and achieves this end by the assessment of each individual aspect of the proposed experiment. The systematic scrutinisation of factors such as species and number of animals involved, methodology and types of procedures proposed, general care and accommodation of animals and so on, coupled with the exploration of alternative means of carrying out the research aims to safeguard against the traditional criticisms of animal research. Issues of pain and distress It is no doubt inevitable that there will still be experimentation in which the animal is subjected to some discomfort or even pain, however the Code provides some guarantee that this would only occur where such research is essential, of wide application and benefit to humans, no other viable alternative to the procedure has been identified, and such pain or discomfort would be minimised as much as was possible. Animal research, as a valuable tool in the science of psychology cannot be discounted. The current situation with respect to methods, technology and oversight is markedly different to that preceeding the 1970s and concerted efforts have been made to limit the negative impact of research on test subjects. It is in this atmosphere that the viability and suitability of the continued use of animals in research can be more forcefully argued. Animal research has contributed to efforts to sustain both humans and animals as a species. It has been responsible for enhancing humanitys knowledge about brain function, emotion, learning and language, and led to the development of biochemical and behavioural therapies. The impact of this knowledge resonates today. The advancement of understanding should not be punished by the sins of the past, therefore providing the proposed research meets the benchmarks set by the Code and legislation, there is no reason why it ought not to proceed. Evidence may well emerge many years later to alter that view, but it is most likely to come only as a result of animal involvement in research. The current evidence suggests that with due consideration to the benefits accruing to all animals, dispensing with animals in research is incommensurate to the perceptible risks associated with their use today.

Friday, September 20, 2019

Methods for Prevention of Post-ERCP Pancreatitis

Methods for Prevention of Post-ERCP Pancreatitis Prevention of post endoscopic retrograde cholangiopancreatography pancreatitis Abstract: Pancreatitis is the most common and important complication of ERCP. Several risk factors exist that help to formation and progress pancreatitis. These risk factors may be factors that are related to patient, and factors that related to Procedure, or factors related to operator. All of the risk factors should be considered and as far as possible may be lowered with attention to pathogenesis of the development of post-ERCP pancreatitis. These pathogenesis are include: sphincter spasm, infection, contrast toxicity and pancreatic secretion that induce activation of proteolytic enzymes and inflammatory process. Some of methods and pharmacologic agent assessed for prevention pathogenesis pathway to decrease post-ERCP pancreatitis. Introduction: In about 75 percent of patients after endoscopic retrogradecholangiopancreato-graphy (ERCP) may have elevation in serum amylase ; but acute clinical pancreatitis (defined as a clinical syndrome of abdominal pain and hyperamylasemia) is less common. However, acute pancreatitis is the important complication of ERCP and need to pay attention it to prevent from its morbidity and mortality [1]. Mechanism for post ERCP pancreatitis: The exact mechanism for PEP is unknown. It needs to be a trigger event that turn on the inflammatory process, that can be the fallowing: thermal injury from sphincterotomy, mechanical obstruction to outflow of the pancreatic secretions , papillary edema from attempted multiple cannulations, sphincterotomy etc., injury from guide wire, chemical injury of the contrast, microbiological injury due to introduction of duodenal flora into the pancreas etc [2]. Risk Factors for Post-ERCP Pancreatitis: It is important to identify cases in which there are high risks for pancreatitis that we can prevent the complications of the prophylactic method such as pancreatic stenting or pharmacological prophylaxis. Assessment of both patient- and procedure-related factors is necessary to detect the high-risk cases (Table 1) [3]. Table 1: Risk Factors for Post-ERCP Pancreatitis [3]. Definition of post ERCP pancreatitis: To diagnose PEP need to be at least two of the following criteria: Epigastric pain with radiation to the back, Elevation of amylase and / or lipase at least 3 times higher than normal. Radiological imaging that suggests pancreatitis. Amylase and lipase may have an elevation despite the patients does not has any symptom. Radiological imaging is helpful when the diagnosis is difficult [4]. Methods and pharmacologic prevention of post-ERCP pancreatitis A. the Following techniques should be adhered to in order to decrease the risk of post-ERCP pancreatitis: 1. Endoscopic techniques 2. Cannulation 3. Electrocautery 4. Pancreatic stenting B. Pharnacologic prophylams: Nonsteroidal anti-inflammatory drugs Steroidal anti-inflammatory agents Other anti-inflammatory agents   Allopurinol semapimod- interleukin 10- pentoxifylline- Platelet-activating factor-Epinephrine Inhibitors of pancreatic secretion: Somatostatin- Somatostatin combined with diclofenac- octerotide- calcitonin Agents that stimulate pancreatic secretion and reduce sphincter tone: Secretin Agents that reduce of sphincter tone: Nifedipine-Nitrates-Glyceryl trinitrate botulinum toxin-topical lidocaine Inhibitors of protease activation: Gabexate mesilate- Nafamostat- Ulinastatin- C1-inhibitor- Heparin Antioxidants: N-acetylcysteine- Sodium selenite- Beta- Carotene Antimicrobial agents Antimetabolites : 5-FU (5 Fluoro Uracil)[5]. Some of the drugs that tested in different trials are described below: Pharmacological Prevention for Post-ERCP Pancreatitis: Since the introduction of ERCP, numerous pharmacologic drugs have been assessed to prevent post-ERCP pancreatitis based on their pharmacologic mechanism and their effect on one or more of the factors associated with pancreatic damage (Figure 1) [6]. 1- NSAIDs: NSAIDs (diclofenac or indomethacin) are the most drugs that are using for prevention of post-ERCP pancreatitis [7]. The European Society of Gastrointestinal Endoscopy recommends routine rectal administration of 100 mg diclofenac or indomethacin for prevention of post-ERCP pancreatitis [8]. 2- Glyceryl trinitrate: Glyceryl trinitrate reduces sphincter of Oddi pressure and may uses to prevent post-ERCP pancreatitis. ManuelMoretà ³ in his study assessed that could transdermal glyceryl trinitrate be effective in the prevention of post-ERCP pancreatitis? The results of his study show that transdermal glyceryl trinitrate patch significantly reduces post-ERCP pancreatitis [7]. 3- Nifedipine: Calcium channel inhibitors can prevent the development of experimental pancreatitis. Nifedipine is from the calcium channel blocker drugs and its effect is reducing sphincter spasm. Part done randomized, placebo-controlled trial to determine whether the calcium channel blocker nifedipine prevents post-ERCP pancreatitis. Nifedipine or placebo was administered before and within 6 hours after ERCP. This study failed to show significant effect of nifedipine in the prevention of post-ERCP pancreatitis [8]. 4-Antibiotics: Infections that occur when ERCP is done can activation proteolytic enzymes and lead to pancreatitis. Now there is this question that antibiotics can use in the prevention of post-ERCP pancreatitis. One prospective randomized controlled trial showed that the ceftazidime administration before ERCP significantly decreased the incidence of post-ERCP pancreatitis in the control group that did not receive antibiotic [9]. The quality of the study is questionable because the control group did not received no antibiotic [10]. 5- Risperidone: Ulinastatin inhibited systemic inflammatory responses and may benefit for prevention post-ERCP pancreatitis. Tsujino assessed the effect of risperidone (a selective serotonin 2A antagonist) combined with ulinastatin for the prevention of PEP in high-risk patients. In a multicenter, randomized, controlled trial, patients were randomly compared to administration ulinastatin with or without risperidone. The incidence of PEP was not significantly different between two groups, but pancreatic enzymes level were significantly lower in the risperidone+ulinastatin group as compared with ulinastatin alone [11]. 6- Indomethacin Indometacin is from nonstroidal antiinflamatory drugs that are used for prevention of post-ERCP pancreatitis. Joseph Elmunzer in a multicenter, randomized, placebo-controlled, double-blind clinical trial assigned patients that were high risk for post-ERCP pancreatitis to receive a single dose of indomethacin or placebo immediately after ERCP. Among patients at high risk for post-ERCP pancreatitis, rectal indomethacin significantly reduced the incidence of the post-ERCP pancreatitis [12]. Yaghoobi also assigned one meta-analysis to assessed rectal indomethacin for the prevention of post-ERCP pancreatitis. This meta-analysis showed that the rate of pancreatitis was significantly lower when using indomethacin as compared with placebo. [13]. 7- Corticosteroid: Corticosteroids are anti-inflammatory drugs and may be able to decrease the risk of post-ERCP pancreatitis. In a prospective randomized controlled multicentre study, administration of prednisone did not reduce the incidence of pancreatitis rather than placebo [14]. 8- N-acetyl Cysteine: N-acetyl Cysteine can reduce inflammation and may be useful in post-ERCP pancreatitis. Pezhman Alavi Nejad wants to evaluate efficacy of N-acetyl Cysteine for the Prevention of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis. He assigned a prospective double blind randomized study. There were significant reduce in the prevalence of acute pancreatitis between the groups. This study shows that NAC could be used for the prevention of post-ERCP pancreatitis [15]. 9- Aprepitant Aprepitant is one drug from the classification of neurokinin-1 receptor antagonists. Upendra Shah wants to assess the efficacy of aprepitant at preventing post-ERCP pancreatitis in high risk patients. A randomized, double-blind, placebo controlled trial assigned. Patients received either placebo or oral aprepitant. Aprepitant could not decrease the incidence of post-ERCP pancreatitis against placebo [16]. pancreatic stents: Abhishek Choudhary assessed a meta-analysis and to determined effect of pancreatic stents for prevention of post-ERCP pancreatitis. This meta-analysis of the RCTs showed that pancreatic stent placement reduces the incidence pancreatitis and hyperamylasemia [17]. Conclusion: Considering the fact that pancreatitis is the most important of the ERCP complications we should pay attention the methods for prevention of post-ERCP pancreatitis. Pancreatic stents are useful for this aim. From the pharmacologic agents, Glyceryl trinitrate, Indometacin and N-acetyl Cysteine could significantly decrease the incidence of post-ERCP pancreatitis. Other drug that assessed in this review article such as Nifedipine, Risperidone, Corticosteroids, and Aprepitant did not show significant effect for prevention of post-ERCP pancreatitis.

Jane Addams essays

Jane Addams expositions Jane Addams was conceived on September 6, 1860 in Ceadarville, Illinois. She entered the Womans Medical College o...